Brenda Wesa, Calgary. The Difference Between DIM and Sulforaphane (the clogged toilet analogy). United States, Department of Health and Human Services, Centers for Disease Control and Prevention. My concern is that I am on birth control -I plan to get off it but I want to do it once I am totally ready. Medications Certain medications like birth control pills and hormone therapy can boost estrogen levels to an unhealthy level. The dosage range of 200mg/kg C-phycocyanin (1g/kg spirulina) converted to human equivalent doses from rats is approximately: 11.0g for a 150lb person 14.5g for a 200lb person 18.2g for a 250lb person Talking with your health practitioner about options for supporting Phase II (like the Estrogen Reset Kit) is a great idea. It is good to eat the foods that have natural (DIM) and you can learn more about these from the workshop http://www.cookingforbalance.com Supplements are your amplifiers and healing accelerators. Start with 100mg of DIM. The symptoms range from lumpy and fibrocystic breasts to thyroid nodules, hot flashes, fibroids, uterine polyps, painful, heavy or irregular periods to infertility and miscarriages, from mood swings to insomnia, weight gain to fatigue. You should also test your hormone levels, including SHBG, total and free testosterone, estradiol, and progesterone. Lots of the info above has the source linked for further reading, just click the highlighted word. I am not aware of any contraindications between Maca root and these supplements, however, it is best to refer to the advice of your medical professional. Is that also true for birth control pill? I have of course schedule an appointment with my gynecologist but that is in a month. Hair loss: Hair loss usually occurs due to perimenopause and menopause, but if you're too young then estrogen dominance can be the main cause. There are different schools of thought about estrogen dominance, but the theory behind it is that during the transition into perimenopause, the body will produce less progesterone but keep producing the same levels of estrogen. Sulforaphane supplements are not made equal (what to look for). Misconception #2: I need to lower my estrogen intake and avoid food high in estrogens (called phytoestrogens, such as flaxseed) because Im already estrogen dominant. The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. This is particularly true for women who are experiencing the symptoms of hormone imbalance. This is because adaptogens have a balancing effect on something called the hypothalamic-pituitary-endocrine axis. We live with hot flashes. Estrogen dominance is a term that is used to describe a scenario in the body in which the influence of estrogen on cellular function is higher than what is considered "normal". I suffer from ED and have been taking a form of DIM and Calcium d Glucoranate and my symptoms are getting worse. https://hormonesbalance.com/articles/best-supplements-for-estrogen-dominance/ []. Do you advise these supplements. ~HB Team. The body has an amazing ability to heal. The benefits of progesterone. A standard daily dose of spirulina is 1-3 grams (g), but doses of up to 10 g per day have been used effectively ( 1 ). document.getElementById( "ak_js_1" ).setAttribute( "value", ( new Date() ).getTime() ); Your email address will not be published. In males, they can cause breast tissue growth, erectile . U need to talk about our needs cause Im sure there are a lot of us out there needing help too. 3. Some types of algae like chlorella and spirulina are prominent anti-estrogenic foods. Plus: Causes, Symptoms, and Treatment Options, Which Form of Magnesium is Right for You? More than 70% of women experience Estrogen Dominance. Did you find anything else out about it and what you can do instead? Hello, I have tried taking the Dim Supplement. The supposed fix for this is sulfate-free shampoo and rinse with vinegar. We are hoping you have found some answers for your daughter. The Environmental Working Group has a great list of, This delicate dance between your brain and hormone system, includes your brain-adrenal (HPA) axis, brain-thyroid (HPT), and brain-gonadal axis (HPG). My OBGYN stays very on top of my testing for breast, and ovarian cancers and I am good. ~HB Support, [] Wszelaki, M. (2021, May 20). As described above, "estrogen dominance" involves a discrepancy between estrogen and progesterone. Healthy regards, HB team, [] Best Supplements for Estrogen Dominance HormonesBalance.com [], We have not had any reports on DIM causing dry skin. He is the host of the popular The Art Of Being Well podcast and the New York Times bestselling author of Intuitive Fasting, Ketotarian, The Inflammation Spectrum and the brand new bookGut Feelings: Healing the Shame-Fueled Relationship Between What You Eat and How You Feel. ~Deanna HB Team, I have a fibroid the size of a tennis ball, is the fibroid kit better than the estrogen dominance kit? So, it will depend on what kind of support the liver needs. I am dealing with all of this right now in meno and its a hard road, but getting the appropriate help and treatment and avoiding those pills and traditional drs that cannot help is an important part of the process. Furthermore, it helps if the sulforaphane formula contains vitamin C research shows an even higher bio-availability of sulforaphane. Make sure that your diet is healthy and balanced to ensure that you're getting all the nutrients your body needs to heal and function properly. EstrogEstrogen dominance increases levels of thyroid-binding globulin (TBG). I think this list pretty much describes a nightmarish myriad of symptoms for any woman. But, its low cost enough to try it! This one is a pervasive misconception that has been copied-and-pasted by bloggers without fact checking. Reason #2: The way your body is breaking down estrogens to the various estrogenic metabolites, is not favorable to you. Hi Laura, Thanks a lot for your answer, Hi Julie, thank you for reaching out. While estrogen is predominantly a female hormone, men have small amounts too. ), the increment in inflammatory agents in day-to-day life are enhancing the estrogen (or estrogen mimic) level, fueling 'estrogen dominance'. It targets biological pathways that both modulate Phase I enzymes and elevate Phase II enzymes, allowing for full and proper detoxification of unsafe chemicals along with dirty estrogens. We have Calcium D-Glucarate in our Wellena store. You will have to check them out to see if that is a fit for you. Your adrenals also need B vitamins, fatty acids, minerals like magnesium, and amino acids like []. However, if your liver isnt functioning properly, it wont be able to break down estrogen causing it to accumulate in your body. It plays an essential role in other body systems, too. ~Deanna HB Team. It can be very hard to completely avoid estrogen excess, because we are surrounded by endocrine . Relative estrogen dominance: You have too much estrogen relative to progesterone. HormonesBalance.Com. ~Deanna HB Team. ESTROGEN DOMINANCE IN MEN & WOMEN It's common knowledge amongst medical professionals that . It works right alongside your liver as one of its primary purposes is detoxification. https://hormonesbalance.com/articles/adrenals-articles/how-to-trust-a-brand-of-supplements/, Also, we recommend starting out with one new supplement at a time, that way you can have a better idea as to what is causing certain symptoms. [] of B6, B12, and Folate are needed for healthy cell signaling and function, including that of breast and cervical cells. Some may have found it makes estrogen symptoms even worse. Smaller dose with something else to help with reactions? I am 86 years old an had cancer of the blatter, they call it the safe kind the does not grow. I also want to mention that I work with a hormone doctor. This excessive cellular activation of estrogen receptors results in characteristic symptoms that can be identified and treated. ), The DIM we make provides 100 mg of DIM (Diindolylmethane) a type of compound known as a plant indole.. Her top 3 recommendations for resolving estrogen dominance are DIM https://hormonebalancenutritionals.com/collections/single-products/products/estro-support, Calcium D Glucarate https://hormonebalancenutritionals.com/collections/single-products/products/calcium-d-glucarate and Brocco Power https://hormonebalancenutritionals.com/collections/single-products/products/brocco-power. Understanding this condition is a pivotal first step towards treatment and better health. ~Deanna HB Team, I am experiencing hair loss .i am 65 and went thru menapause at 52 The immune system: Furthermore, this study shows calcium d-glucarate decreases inflammation by activating the immune system and increasing the activity of the anti-inflammatory cytokines. Sometimes, the term "estrogen dominance" is used interchangeably with "high estrogen.". Since hormonal birth control prevents ovulation, that is often another contributor. DIM also acts as an aromatase inhibitor it means that it can block some testosterone from converting to estrogen, making more testosterone available in the body (can be a good thing). Hi Caroline, 7. Estrogen is a female sex hormone produced by the endocrine system whose main role is promoting growth. There is literally ZERO data out there for someone like me. Veronica, HI Vera, DIM supports Phase I of liver detoxification, however for complete estrogen metabolism and detoxification you also need to support Phase II. We recommend taking these three supplements with food. Also, it is recommended to start with the Fibroid Kit https://hormonebalancenutritionals.com/collections/frontpage/products/fibroid-kit first and if more support is needed, then follow with the Estrometabolizer Kit https://hormonebalancenutritionals.com/collections/frontpage/products/estrometabolizer-kit. Spirulina cells do not have cellulose. This explains why many women either feel their symptoms of ED lift for a few weeks, and then start feeling worse. It supports Liver Phase II, glucuronidation pathway detox. In Overcoming Estrogen Dominance, I hope to show that those extreme interventions are often unnecessary, and to give women a roadmap to reverse Estrogen Dominance using food, herbs, supplements and natural protocols to rebalance hormones. How Does A Body Become Estrogen Dominant. More than 70% of women experience Estrogen Dominance. Please also reach out to our team at [emailprotected] if we can answer any other questions or do more to support you. so I stopped. This delicate dance between your brain and hormone system, includes your brain-adrenal (HPA) axis, brain-thyroid (HPT), and brain-gonadal axis (HPG). A third sulfur-containing compound, known as sulfites, is a form of preservative that can cause allergic reactions in some individuals. Sulfa-based drugs, also known as sulfonamides, do not occur naturally and are used as antibiotics. Spirulina is about 20% C-phycocyanin by weight, and about 1% phycocyanobilin by weight. Naturally now Im concerned about the estradiol cream (of course I got in touch with my doctor and am currently waiting for a response). ~HB Support. DIMs proven safety means that DIM can be used by women wishing to get pregnant but should be discontinued during pregnancy and lactation. These foods contain soy isoflavones, which increase estrogen production 1. Firstly thanks for writing this article it has been so informative. You recommend 3-7g of Brocco Power in this article, but the recommended dose on the bottle is 500mg 1/day. Overwhelmed with where to start? Thanks. If the symptoms do not subside, add DIM and Calcium D-Glucarate. If you need more ideas, read, Olsson, Erik M et al. I am reluctant to try a lower dose with this severe reaction. Ive just bought vitamin C 1000 Hi Sarah! I read all of the information and currently take dim myomin and progesterone cream for estrogen dominance. I want to do a sulfur elimination diet so I am very confused . @ Kris C I am 44 and have had some hair loss on my head, but hair on chin is getting thicker. Glucuronidase (beta-D-Glucuronoside glucuronosohydrolase) is an enzyme that hydrolyzes a glucuronide, especially the beta form of a glucuronide. Here is her free preview link https://hormonesbalance.com/cfb/watch/ ~Deanna HB Team. Fibroids/ Endometriosis. This can include shutting off electronics an hour or two before bed, a 15 minute mindfulness practice, or sleeping with a weighted blanket. First, let's talk about the symptoms of estrogen dominance. Depression / anxiety /irritability/unusual mood swings. Estrogen dominance can cause the following: Decreased libido Mood swings Allergies Headache Increased premenstrual symptoms Irritability Fatigue Infertility Fibroids or benign tumors in the. Liver support is key A thought to consider, some of our international followers have started using Myus.com (a third party shipper). Thank You for sharing this useful information, Every woman should know it, I got through this blog has really helped me in understanding this topic. Certain medications like birth control pills and hormone therapy can boost estrogen levels to an unhealthy level. Does seed rotation diet will help also, Or one should eat only the progestron supporters e.g. If you are after cancer treatments, the products have not been contraindicated for ER+ cancers treatments including Tamoxifen and Raloxifene. (2) This is important for many reasons but its especially important for your hormone health. First, they support liver function and detoxification so your liver can package up estrogen and excrete it through your stool. Although every persons health case is unique, there are a few tools that can help you rebalance estrogen levels by addressing the most common triggers of estrogen dominance. ~Deanna HB Team, Hi, would it be okay to take the wise womans balance while having a hormonal IUD? In Overcoming Estrogen Dominance, my goal is to empower and give you the tools to take control of your hormones and health. Is there something else to try? Many cheaply-made supplement manufacturers dont use this formulation approach leaving the product efficacy to chance. If you are highly symptomatic (and experience things like fibrocystic breasts, stubborn breast lumps, advanced endometriosis, quickly growing fibroids), start with all three products: You can save money when you get the Estrogen Reset Kit, which contains all three of these products. I have Rheumatoid Arthritis and 3 other minor auto immune diseases. You can take it as a supplement or drink it as tea. With a blood test? Anti-carcinogen and detoxifier: Research shows when it comes to supplementing with sulforaphane, premenopausal breast cancer risk was decreased with higher broccoli consumption, it can increase the activity of detoxification enzymes, its effective in reducing thyroid cancers, and it raises OH-2 estrone, which is the protective form of estrogen. You are high in testosterone and you convert testosterone to estrogens. While many people are allergic to sulfa drugs, no similar reactions have ever been reported with MSM. Most women with ED do not suffer because of too much estrogen but because they are not breaking down and evacuating these estrogens well enough. Find a sulforaphane supplement that guarantees 3 to 7 grams of sulforaphane (not just glucoraphanin), provides myrosinase, and preferably contains vitamin C. We formulated our Wellena Brocco Power exactly this way and I believe it is one of the top products in the market. Named one of the top 50 functional and integrative doctors in the nation, Dr.WillCole provides a functional medicine approach for thyroid issues, autoimmune conditions, hormonal imbalances, digestive disorders, and brain problems. I just got the results from a genetic test that showed my estrogen metabolizing pathways in the liver are pretty much busted. ), or 7. Derived from broccoli sprouts, it has similar characteristics to DIM but is not quite the same. In fact, studies have shown that a lack of sleep can lead to chronically elevated cortisol which doesnt do your progesterone or estrogen levels any favors. With DIM, you have just unclogged your toilet bowl but not the drain. It could be helpful to discuss incorporating any supplements into your treatment plan with a functional medicine practitioner. Yes, that is a sign of estrogen dominance. Spirulina is a blue-green algae commonly used as a dietary supplement. The dark green color gives them anti-estrogenic properties . Estrogen-Dependent Cancers. If you are experiencing any of these symptoms, the best way to know for certain is through lab testing. Fighting for my life now at age 67. Due to its detoxifying and anti-inflammatory properties, it can help reduce cramps, breast tenderness, and inflammation while improving mood + overall hormone balance! Do you plan on keeping the IUD in place? Im very curious as I am on bioidentical HRT and would like to take DIM. When I had lumps on my breasts and water retention that forced me to take all my rings off, I did DIM and Brocco Power for 2 months to quickly rebalance my hormones and reduce all the symptoms. Alcohol stimulates appetite and decrease your testosterone levels for up to 24 hours and increases estrogen by 300%. Synthetic hormones in north control actually lower the natural estradiol in the body for girls with PCOS after withdrawing. Talking with your functional medicine practitioner is always a good idea if youre unsure about continuing to take DIM. As one of the first functional medicine telehealth clinics in the world, we provide webcam health consultations for people around the globe. Hi Julie, If you know you are sensitive you will want to avoid them. Summary. This research validates cancer prevention and estrogen metabolism. Hey, I just started DIM Im taking the Zhou product which is 250mg per tablet and I have been taking 1 a day for just over a week. The way to solve this is to combine DIM with Phase II liver detoxifiers sulforaphane and calcium d-glucarate. Sulforaphane is a compound high in broccoli sprouts. If you suspect that you are struggling with estrogen dominance, schedule a consultation to learn more about how you can alleviate your symptoms naturally with functional medicine. Women have been led to believe that at the earliest symptoms of perimenopause and menopause, they should run out and get hormone replacement. More on these, below. 75,2 (2009): 105-12. doi:10.1055/s-0028-1088346. can these 3 supplements reverse endometrial cancer? Get FREE access to these + giveaways, recipes, & discount codes in personal emails from Dr. Will Cole. is estrogen dominance, particularly among women. My bowels are also sluggish and I feel a bit constipated. Are these symptomatic of ED, and if so, which supplements would be most helpful? DIM is made up of a crystalline structure that makes it difficult for the body to absorb. This is especially important considering your hormones are considered chemical messengers, directing the function of various areas of your body. Sixty four young adult male rats were used and divided to 8 equal groups. This happened to me too Any information on if this is okay to keep taking? Even a dermatologist, unless they are specialists in female hair loss, will often prove useless. Since cortisol is elevated during times of stress, the focus should be on implementing stress-reducing tools throughout your day. I am on Synthroid. The only thing you want to lower is xynoestrogens (synthetic or external estrogens) found in commercial skin care products, perfumes, and cleaning products. Side effects and downsides Although spirulina. Both chronic and acute stress can cause hormonal imbalance and thus estrogen dominance issues. Use Food as Medicine to Reduce High Estrogen Support estrogen clearance. Spirulina nutrients help support your liver, which is the primary place of detoxification processes and is very important for hormone metabolism. Without proper progesterone levels, estrogen becomes out of control, also known as estrogen dominance. Hidden cause of your hormone imbalance #3 - Herbicides If you are experiencing any of these symptoms, the best way to know for certain is through lab testing. Calcium d-glucarate can speed up the metabolism of toxins and decrease the effectiveness of medications changed by the liver. Thank you for your question. Estrogen dominance is when a woman's levels of estrogen and progesterone, another sex hormone, are out of balance. This tiny alga is packed with nutrients. Anyway, I asked a naturopath about the hair loss and long story short you may want to look into this scenario: sulfates in shampoo cause testosterone on scalp to turn into dht or a bad form of testosterone which weakens follicle, then hair falls out. More women need to know about this estranged driven cancer. At 39 years old I began to gain weight no matter what I did so after much research I found a clinic that FINALLY checked ALL my hormones and I found out I had NO detectable progesterone or testosterone in my body, my estradiol was low and my Estrone was about 6 times higher than my estradiol levels which explained my weight gain, acne and all my other symptoms. Then, you could slowly add them back in (one at time) to see if you can pinpoint the issue. 4. When it's over-stimulated, you may suffer fluid retention, constant anxiety, tummy troubles, weight gain and lowered immunity. Maca to the rescue! These labs look at sex hormones like estrogen, progesterone, and testosterone as well as cortisol levels and your HPA-axis function. I used atural progesterone to get through menopause symptoms and for bone health. B vitamins act as fuel for methylation and help boost your bodys ability to detox and break down estrogen. ~ HB Support, HI Heather, Can I take both DIM, CDG and my BC pill without fearing it to be less effective? These statements have not been evaluated by the Food and Drug Administration. I am happy to hear that you have benefited from this article! Anxiety in turn can cause physical symptoms like palpitations, panic attacks, etc. Information is shared for educational purposes only. Estrogen dominance is all too common for women these days. 2. In this study we aimed to investigate the effects of SP on the testicular structure and relation between ghrelin and testosterone in the testis of rats fed a high fat diet (HFD). I had a very severe headache, and spent the good part of the night trying not to throw up. Some women feel worse right away. Without combination HRT, you will consistently show ED signs because your progesterone is so low it cannot counter balance the estrogen. I was also given Progesterone to balance the estrogen and I cannot take it at all, I flare up and get sick. Exactly How This Superstar Supplement Can Benefit Your Health, Your Definitive Functional Medicine Guide To Autoimmune Disease: Symptoms, Causes, Supplements + More. Ive been experiencing gut issues and bloating that I think might be associated with the progestin that has been introduced. However, just because something is common doesnt mean it's normal. In fact, a lot of women struggle with this issue and dont even realize that it is something to be aware of. ESTROGEN-FREE PROTEIN POWDER (WHEY ALTERNATIVES) Estrogen dominance happens in the body when there is estrogen overload or too much estrogen in relation to progesterone. Our content may include products that have been independently chosen and recommended by Dr. Will Cole and our editors. Per our supplement expert, you should have no issues with DIM as it does not contain sulfur or sulfites. High estrogen levels can cause symptoms such as irregular or heavy periods, weight gain, fatigue, and fibroids in females. Healthy regards, HB Team. Symptoms of estrogen dominance can look different for every person and also look different for men and women. DIM has been marketed by many companies as the estrogen buster. Yes, it does have all the benefits I covered but note that it only upregulates Phase 1 liver detoxification. Im a big fan of getting sulforaphane from broccoli sprouts, but if you dont have the time or access, a supplement is a good option. Hi Jeanette! FUNCTIONAL MEDICINE CONSULTATIONS FOR PEOPLE AROUND THE WORLD. 2. Thank you! The sulforaphane supplement we carry is called Brocco Power. Why has DIM stopped working or made you feel worse? These algae accelerate detoxifying effects in the liver, and the well-cleaned liver flushes out estrogen at a better rate. If one added more progesterone, it will lower the estrogen levels, so both are in balance again. I am now 46 years old but at 26 years old I lost my uterus, ovaries, cervix, and tubes due to endometriosis. I would very much appreciate your input and of course will run it by my doctor (who may not know about DIM). Thanks! Or is it just like taking a daily multivitamin and good practice long term? The human body produces sulfites in its normal metabolism of sulfur-containing amino acids. Women are feeling tired, facing period problems, dealing with "menopausal" symptoms earlier and earlier, and are desperate for solutions. Working with a functional medicine expert can help you determine if estrogen dominance is a factor in your health case and the best steps to rebalance your levels. Has none of the side effects associated with I3C. However, if you are dealing with a persistent type of Estrogen Dominance or serious conditions such as a large fibroid, breast, or thyroid cancer, I recommend considering supplementing with a high-quality sulforaphane supplement. There's a fine balance between the two as progesterone is generally a calming agent against estrogen's pro-growth effects. So, we cannot comment on that one. Youve made a lot of posts regarding estrogen dominance but nothing on young girls that suffer from low estrogen and high testosterone. 3. Broccoli sprouts and sulforaphane content. One of its functions is to bind estrogen to assist the body in eliminating, making room for the new estrogen the body makes on a regular basis. We actually can have 3 types of estrogen in the body. Many thanks. According to the United States Department of Agriculture (USDA), one tablespoon or 7 grams (g) of dried spirulina. Chlorella and Spirulina are completely dark green, i.e. Just wanted to know, if DIM can u make you bloated when u start taking it? Im so smitten by it that I may sound like a snake oil salesman. Hope this helps! Progesterone is produced by the ovaries, placenta and adrenal glands and is . Key Concepts for COMT and Estrogen. I did experience a time in which I was able to achieve a balance between Estradiol and Estrone and when I did I dropped 30lbs in 3 months, it was so fast my hair began to fall out. Many people with immune problems have genetic methylation impairments, such as MTHFR gene mutations, which makes it difficult to detox on your own. The Elimination Diet is the best diet to start with according to Magdalena. Meaning, DIM and Calcium D-G together, and the Brocco separately. There are many ways to affect your hormone balance and lower your estrogen and progesterone, including lifestyle changes and prescription medications. In addition to helping aid in the bodys detoxification, sulforaphane has been shown to have long-lasting antioxidant effects, offering protection from oxidizing free radicals and anti-estrogenic cancer properties. 2 2-OH methoxy estrogen is very important for health and it helps to prevent other symptoms of estrogen dominance such as PMS, heavy bleeding, fibroids, endometriosis, etc. Most people who have estrogen dominance experience a handful of the following symptoms. Although your estrone, estriol and estradiol may be in balance, the problem with estrogen dominance is that even with a good balance of the above 3, if your ratio to progesterone is out of balance, or the metabolites for the estrogen being broken down is imbalanced, you may still struggle with ED symptoms and experience acne, weight gain, hair loss, mood swings and more. Both men and women also need healthy progesterone levels to keep estrogen balanced. Veggies like broccoli, kale, brussel sprouts, bok choy, cabbage, and cauliflower have two big benefits for estrogen balance. Hb Support. We discovered that my iron levels were extremely low and I was heavily estrogen dominant. When Ive used DIM in the past, my liver enzymes became elevated, apparently a rare reaction. Hawaiian Spirulina - rich in beta carotene, vitamin B12, and a variety of minerals and esential amino acids, this species of spirulina has anti tumor properties, and . You should also conduct complete nutritional tests to cover the range of nutrients you need for healthy hair, skin, etc. Spirulina and chlorella are both extremely high in chlorophyll (leaf green), which has anti-estrogenic properties. It may depend on which pathway of the liver is struggling. Had breast ca. Spirulina and chlorella (the best kinds of algae) are both known for their effects on detoxifying the liver, and when your liver is clean then it flushes out estrogen with a much better rate. A high quality fish oil is absolutely essential when you are trying to reverse estrogen dominance naturally. Kefir is a good source of conjugated linoleic acid ( CLA ), which has been shown to inhibit the growth and migration of breast cancer cells. We can only imagine the stress going through all of this caused for you. When it comes to working out, more is more, right? A diet high in fat or low in fiber could lead to higher estrogen levels. If you purchase something mentioned in this article, we may earn a small commission. Estrogen dominance is when the body has too many unhealthy, artificial estrogens. It's also linked to estrogen-dependent conditions like endometriosis, uterine fibroids and polycystic ovary syndrome which can be very difficult to treat. Your liver is one of your bodys main organs responsible for detoxification. Commonly known ingredient as MSG used in many of our every day items, including bottled water which is why I have to be extremely careful.