Instead, the government prefers to fund and promote new, proprietary drugs and vaccines, he says. [4] Steve Kirsch - Silicon Valley Philanthropist Shares Review of CDC Data: COVID-19 Vaccine Associated with 100X Deaths Compared to Influenzas [5] Steve Kirsch - FOIA Document for Vaccine Discussion as to mRNA-based Vaccine Safety Signals Added 12th August 2021: Hes also made several videos and podcasts with Vladimir Zelenko, the conspiracy theorist doctor who convinced Trump to take hydroxychloroquine. My website www.skirsch.io has tons of info on fluvoxamine with all the links. It is perhaps the greatest unnecessary loss of life in American history. Molnupiravir followed patients for only 30 days because they know the drug is dangerous. In severe cases, it takes longer. . Steve and CETF funded the research that showed promising results of fluvoxamine as an early treatment of COVID-19. After two weeks (since it was a tight knit community, everyone could see what was happening to the two groups), every track worker who got sick with COVID, demanded the drug. Doctors wait for government permission (EUA or added to the NIH guidelines) before using a drug. They left their recommendation of fluvoxamine at NEUTRAL. Dr. Eric Lenze: So the results were really pretty. It used to be that a Phase 3 study would do it. . ICER Publishes Final Evidence Report and Policy Recommendations on Outpatient Treatments for COVID-19 - ICER. These huge businesses do often prioritize profits over human health: in 2009, Pfizer paid a $2.3 billion settlement over kickbacks and fraudulent marketing, including a $1.3 billion felony fine. . Adverse reactions/side effects. I was just getting tired, he said, before asking to speak off the record. of the 'intellectual dark web '" and allowed him to access a "large and receptive audience to his claims about a fluvoxamine conspiracy". It works best when it is given early, as soon as symptoms start. 47).. The effect size is huge if the drug is given early right after symptoms start. He was recently featured on 60 Minutes which highlighted his . The NIH did nothing despite the fact the that NIH, FDA, CDC, and academic institutions participated in the panel, this is NOT about the science. That was a lie. That way you can start immediately. The alarming article cited the claims of two anti-vaxxers, Steve Kirsch and Dr. Robert Malone. He told me that while he and his family got vaccinated as soon as they were eligible, he got the idea that vaccines are dangerous from a man he hired to clean his carpets, who got very sick after receiving the vaccine. The NIH Guidelines committee is being very slow to react (we have no idea if they are even considering the drug because nobody is allowed to know that because all their deliberations are kept secret). I asked to give a talk about COVID at MIT, but they couldn't find a faculty member to sponsor it. You see this with people who have a lot of money, who think that reflects their intelligence, Richman told me. Once the Phase 2 result came out, it should have been embraced by doctors. What's even worse is that a third of recovered patients from COVID will return to the hospital within 5 months and 1 in 8 die. Steve Kirsch is a high-tech serial entrepreneur based in Silicon Valley. The NIH wrote a bullshit rejection because the FDA told them not to approve it. If you do have a side-effect, it is usually mild nausea which goes away when you stop taking the drug. Telling the truth, he tweeted. An approach that promised to democratize design may have done the opposite. NIH and WHO refuse to acknowledge it works since it will cause vaccine hesitancy if it is known that there is a drug that turns COVID into a mild disease. I took it myself at that dosage and noticed zero side effects. NIH is still unsure whether fluvoxamine should be used to treat COVID. Most recent articles first. Another is to identify an asteroid that is going to hit the planet.. The results would, eventually, set Kirsch on a collision course with the scientific establishment. Fluvoxamine is a well-tolerated, widely available, inexpensive selective serotonin reuptake inhibitor that has been shown in a small, double-blind, placebo-controlled, randomized study to prevent clinical deterioration of patients with mild coronavirus disease 2019 (COVID-19). Doctors who are most familiar with the drug would prescribe it to their patients. Thirty minutes past the end of our scheduled time, he dropped his phone in the cupholder of his Tesla so that he could keep talking while he ran an errand. This drug can save your life but you have to ask for it! Most doctors wont use it until NIH greenlights it, no matter what the science says. In 2013, Johnson & Johnson paid $2.2 billion for its own kickback and fraud scandal, including a specific $400 million fine for its subsidiary Janssen, which manufactures the covid vaccine. It was tested in coronavirus patients because fluvoxamine has very strong anti-inflammatory properties. There were no studies reported out so far where fluvoxamine made things worse or neutral. So you can address your OCD and if you get COVID, youll can up the dose. Steve Kirsch -Executive Director at COVID-19 Early Treatment Fund Ivermection study - One .2mg/kg dose a week for prevention "100% success rate whereas those doctors taking placebo had a 59%% infection rate not a typo 237 of 400 docs on placebo got infected vs. 800 docs on Ivermectin none got infected" Antivirals This site requires JavaScript to run correctly. NIH doesnt want you to get the drug since it would compete with Molnupiravir, so fluvoxamine will never make the NIH guidelines. All this was known back in January 2021 when a key opinion leader panel of experts from NIH, CDC, FDA, academia, and journal editors voted by over 2:1 to recommend that fluvoxamine be recommended to physicians to discuss with patients. Repurposed drugs are safer and more effective than the current vaccines. Lack of action. He's discovered a common medication that's highly effective in minimizing the impacts of COVID-19 - two studies have proven so. 21. Skirsch.io site visitors volume is 1,957 unique day-to-day guests and their 3,914 pageviews. Fluvoxamine public data repository: The fluvoxamine public repository has all the documents related to fluvoxamine for COVID, including the RCT, RWE, observational studies and a link to the 1 hour lecture on serotonin and fluvoxamine. But even she was drained by Kirschs constant attempts to override the data. The ICER independent review showed fluvoxamine is more effective than Molnupiravir: Read this article I wrote about using fluvoxamine correctly for COVID. I agreed to do it partially because I respect Bob [Siliciano] so much, and partially because I thought the concept was excellent, said former board member Doug Richman, a prominent HIV drug researcher at the University of California San Diego and former member of the funds scientific advisory board. Every earlier study of fluvoxamine (such as observational studies) showed it work and the mechanism had been shown. Why not fluvoxamine? If you cant get a prescription for COVID, then perhaps you have OCD? If you start later, doctors use higher dosages and compliance becomes a bigger problem. It cant be more clear than this. Other SSRIs work as well, but fluvoxamine activates the Sigma-1 receptor the most of the SSRIs which is why it was chosen. Still, in the moment, his question threw me, and I stuttered. P-value was 10^-14 on that study (done by Dr. Seftel). To date, the #1 drug with the most evidence to make a significant difference, without any doubt, is fluvoxamine. In October, the group reported that, while a few patients in the placebo group ended up in the hospital, none of the patients receiving fluvoxamine got sick enough to go. I couldnt tell I was on the drug. Kirsch told me that meta-analyses are a higher level of evidence than randomized controlled trials. When I responded that meta-analyses are only as good as the data they are based on, he said Id like to understand your source on that, because I cant find a source that says a phase 3 trial is greater evidence than a meta-analysis., When you characterize me, you need to say that Steve Kirsch doesn't go with majority votes on interpreting data.. Sage Hana. . Fluvoxamine has a 40 year safety track record. Steve Kirsch cut the check, which allowed Dr. Lenze to finish recruiting the 152 patients he needed for his trial. My favorite dosage is 50mg twice a day for 14 days. We need to keep people out of the hospital in the first place. Proven in clinical use all over the world. Fluvoxamine is the poster child of the COVID-19 Early Treatment Fund (CETF). My website. Fluvoxamine - The backstory T he i nsi de st ory behi nd how f l uvoxami ne became a CO V I D t herapy By Steve Kirsch Last updated: June 3, 2021 . The medical community did nothing (with a few exceptions like Dr. Seftel). [NIH] doesnt want any of these treatments. I wanted to get the article out before my flight left. Less than a week later, David Seftel read about the Lenze trial, and ignored the JAMA advice. To scientists, giving fluvoxamine a chance means running a large trialnot giving it to individual patients in the clinic, off-label and outside the context of active data collection and analysis. The. . It is currently approved for treatment of depression and obsessive compulsive disorder (OCD). Skirsch.io traffic volume is 1,957 unique daily visitors and their 3,914 pageviews. The repository goes over the prescribing guidelines, contraindications, and describes the effect on caffeine consumption while on drug (basically you want to avoid caffeine while on the drug). In three phone conversations, as well as dozens of emails, his responses to questions about claims in this story were imprecise or constantly changing. Author Affiliations Article Information. Steve Kirsch, current director of the Covid 19 Early Treatment fund is an MIT alumni who has made a career as a tech entrepreneur. For decades, coders wrote critical systems in C and C++. . Here are the key things you should know about fluvoxamine for COVID: It works. As noted before, the repository has a link to the 1 hour serotonin lecture. Don't underestimate the virus. MisinformationKills. Stopping the meds will return you to your normal self. At the dosing for COVID (50mg BID x 14 days), there is a 1% chance of mild-nausea and because the dose is so low and the time it is taken is so short, and there are no psychotropic effects (which require more than 3 weeks of use; the psychotropic effects non-existent if you don't have depression or an anxiety disorder in the first place). Other SSRIs work as well, but fluvoxamine activates the Sigma-1 receptor the most of the SSRIs which is why it was chosen. Comparison with molnupiravir. See more below. Today, if we follow the CDC advice, nearly 100,000 people a month will die from COVID. Online Status. In some cases, youd want to taper down the dosage. Since FLV is a safe drug, it should have been widely discussed with patients that there is virtually no downside and a huge reduction in hospitalization if the drug is given early. Medicine today isnt about saving your life. So it was both obvious and convincing the difference between the groups to the workers and the track management. None of this would really matter if Kirschs views on vaccinations were private, or shared with a limited audience. Dosage there is 30mg once a day. I see it all the time on social media, Morris told me. are all super cheap, effective, and available without a prescription. Thats pretty typical, but your mileage may vary. It is very safe: There is no evidence fluvoxamine is harmful and led to a worse outcome. Compulsive hand washing? Where did it go wrong. The NIH wrote a bullshit rejection because the FDA told them not to approve it. But fear of trying something new prevents any doctor from giving this drug a try. (The fund borrows its nonprofit status from the 501(c)(3) Rockefeller Philanthropy Advisors, which managed its money until it quit, according to the Daily Beast; neither organization is related to the Rockefeller Foundation, which supports Technology Review's reporting on covid.). By March 2020, hed settled on the idea of searching for covid treatments in the pre-existing pharmacopeia. So probability of successful Phase 3 can be estimated to be over 99.99% since there are tens of thousands of phase 3 studies. I think so. Several other trials around the world are in the final stages, too. If you ask your doctor for any evidence that fluvoxamine doesnt work or is harmful (like a DB-RCT which is the only thing they trust), they will show you nothing. There are reports of people who cant tolerate the drug, but they stop using it and nothing bad happened. 707. Were having trouble saving your preferences. Its a cycle that feeds mistrust and boosts the profiles of influencers who present themselves in opposition to official authorities. He may not be a good scientist, but hes smart, says WVUs Feinberg. Even though they spent only 45 minutes and just reviewed the 2 clinical studies and some plausible mechanisms of action (and ignored anecdotal evidence and multiple retrospective trials, all of which were supportive), after the meeting they voted overwhelmingly (11 to 5 with 4 being neutral) in favor of having doctors talk to their patients about using fluvoxamine if they have COVID using a "shared decision making" process. . This suggests that a 50mg BID loading dose for day one, followed by 50mg QD dose for the following 13 days should also be quite effective. Once the Phase 2 result came out, it should have been embraced by doctors. Those who know Kirsch say this is a typical tactic. But even that didnt last long. The board members I spoke to say they refused to publicly promote any drugs for off-label use and tried to explain to Kirsch that its incredibly common for exciting results from small trials to disappear in larger ones. That way you can start immediately. The collateral damage is that, now, a lot of people dont trust scientific leaders or the scientific community. The External Medicine Podcast - Fluvoxamine as a potential treatment for COVID-19: An Interview with Steve Kirsch. I didnt intend to spend a lot of time on Steve in particular, but that video was so influential.. Kirsch, despite having direct access to the actual trial runner, eventually became convinced a correct interpretation of the data would show that hydroxychloroquine worked. They knew in advance it was coming and on the day the paper was published they ignored it entirely. It was so bad you couldnt even see the babys body through all the blood, Kirsch said. Its sad, but its true, he told me. I've asked people, "there's a lot of evidence here it's not just a small phase 2 RCT. Decreasing the dosage or stopping the medication will mitigate symptoms within hours. This is what the Seftel trial at Golden Gate fields used. Entrepreneur Steve Kirsch who holds an early patent for the optical mouse decided to get involved in treating Covid. 9th International Congress on Psychopharmacology 5th International Symposium on Child and Adolescent Psychopharmacology Ive used it personally at 50mg twice a day and experience no adverse events at all. including the very promising Fluvoxamine. (One of them, Eric Lenze, was in fact giving a presentation on fluvoxamine to the National Institutes of Health the next day.) The FDA is will take months to deliberate on the fluvoxamine EUA application that we submitted on January 29. All can merit a fluvoxamine prescription based on traditional diagnoses. Last Checked: 03/02/2023. Since then, he has continued to promote fluvoxamine, along with ivermectin and hydroxychloroquine. Since making a fortune as the founder of Infoseek, an early search engine that was the Google of its day, Kirsch has spent tens of millions of dollars fighting humanitys biggest threats. Eventually, a press representative who was listening in, David Satterfield, unmuted his microphone to suggest we finish our conversation by email. While YouTube has repeatedly taken down the full video of the DarkHorse episode, various clips have been watched over 4 million times, and the full audio remains available on Spotify. If you wanna find someone to debate me for ten thousand dollars, or a thousand dollars, Im happy to do that, just for your benefit.. In September, Kirsch emailed Morris asking him to estimate the maximum number of deaths caused by vaccines. Try refreshing this page and updating them one Get your prescription in advance of getting COVID. Every earlier study of fluvoxamine (such as observational studies) showed it work and the mechanism had been shown. Refresh. Perhaps Kirschs most effective tactic, though, is simply his willingness to outlast everyone else. Reason is the hospital gets release from liability if they follow NIH guidelines. Fluvoxamine at 50mg twice a day for 14 days is a very well-tolerated drug (as long as you avoid caffeine and alcohol) for the treatment of COVID infections. As of January 18, 2021, the CDC estimates that 90,000 Americans will die from COVID in just the next 3 weeks. What has alarmed many of the scientists associated with CETF, though, are Kirschs reactions to the work hes fundedboth successes and failures. Its not about the science. . At that dose, no side effects were reported for his patients (I know of only one person who had mild nausea at that dose) and everyone reversed out their symptoms in an average of 3 days. Items included in the Television News search service. This is the gold standard of evidence based medicine, Article about the fluvoxamine rejection (The Verge). Compulsive fiddling with your mask? I bumped up the reward to $1M. The combined p value of the two studies is <.0001. All have had a 100% success record in keeping their patients out of the hospital. Fluvoxamine was reportedly added to just 2 practice guidelines (. CETF founder Steve Kirsch accepted an invitation to discuss the findings on a weekly . Steve Kirsch Nov 5, 2021 145 92 Here are the key things you should know about fluvoxamine for COVID: It works. By Steve Kirsch Last updated: March 14, 2021 After I appeared on the60 Mi nut es story about fluvoxamine,I've received a lot of questions from people about how to treat COVID. They all promised me when fluvoxamine passed Phase 3 trials, nearly everyone would use it. He started a new pseudonymous account, @VaccineTruth2, to continue broadcasting messages. This looks ominous, but it harmless. We didnt come up with better mouse technology than Microsoft did. For example, tylenol+caffeine+fluvoxamine can lead to serotonin syndrome. So much for evidence-based medicine. Steve Kirsch Executive Director at COVID-19 Early Treatment Fund (2020-present) Author has 176 answers and 1.7M answer views Updated 1 y Both. . Infoseek lost out to Yahoo; it had a chance to grow bigger, but it didn't. Your best bet is to. Ive talked to doctors who are extremely familiar with the drug and all the trial results and they would prescribe it to their patients. He has a history of giving away some of his millions to good causes, and when COVID-19 began. The medical community doesnt care about saving lives. Note: normally I have lots of hyperlinks to all the sources, but Im pressed for time. But while this effort was praiseworthy, Kirsch's predilection for oversimplifying and exaggerating led him to mislead. Links to evidence about fluvoxamine including the public data repository. ICER, a non-profit known as the nations drug pricing watchdog, did a review of the evidence and determined that fluvoxamine evidence is superior to Molnupiravir. ALWAYS check with your doctor and report any medications you are taking before or plan to take after you start taking fluvoxamine. He is frequently brash and interruptive, peppering dire warnings about vaccines with veiled aspersions toward Anthony Fauci and vague references to influential people who agree with him in private but cannot speak publicly. How can we get fluvoxamine? Theres nothing there.). In some cases, youd want to taper down the dosage. Boulwares trial was part of a wider movement to bulk up the evidence base underlying standard covid treatments, and one of several trials that found no benefit to using hydroxychloroquine. Hes refused to accept the results of a hydroxychloroquine trial that showed the drug had no value in treating covid, for instance, instead blaming investigators for poor study design and statistical errors. Fauci wants the vaccine to be the only option, Cliff Lane works for Fauci, and Cliff follows his orders. A very short op-ed arguing for using fluvoxamine against COVID. If there is a better drug on the table today than fluvoxamine, the NIH panel should put that one on the guidelines. In the early days of the pandemic, as billions of dollars poured into the hunt for novel treatments and vaccines, veteran Silicon Valley entrepreneur Steve Kirsch did what hes always done: He went looking for an underdog. So check the side-effects list to be familiar with which side-effects are associated with which drug so if you have a side-effect, youll know which drug to reduce or eliminate. As of November 13, fluvoxamine has been proven to work in every trial that has published results, including outpatient and inpatient studies. Be warned!. If you were drowning and we had no known standard of care to save your life and someone had a life preserver which worked 160 times in a row, should we throw them the life preserver or let them drown because we aren't absolutely sure the life preserver's benefit > risk (since just because it worked 160 times in a row and there is a 99.99% chance the effect didn't happen by chance, we could have just gotten lucky). In the second trial, it was shown to be 100% effective in long-haul COVID symptoms: None of the treated patients had any long-haul symptoms after 2 weeks compared to 60% of untreated patients having 1 or more of the 15 long-haul symptoms after two weeks, and 29% having 4 of more of the long haul symptoms after 2 weeks. There are now 5 independent observational studies that show that the drug works (2 in France, 1 in Germany, 2 in the US). It does not matter how many lives will be saved. So far, doctors have failed to share his sense of urgency. Fluvoxamine works on hospitalized patients too, but no US hospital will let you use it (sound familiar? He might be a good snake oil salesman., I experienced this myself when, on one call, we discussed several studies. Thats why they didnt change their recommendation when the Phase 3 trial was published in Lancet. Compulsive hand washing? Fluvoxamine is also an Always be self aware when using fluvoxamine. This is the #1 ranked best answer to "COVID treatment" on Quora: Presentation on how fear of trying something new is what keeps us shutdown and leads to unnecessary loss of life: The Lenze fluvoxamine RCT that was published in JAMA on November 12, 2020 showed a 100% success rate in preventing hospitalization. But they dont want their names used. We look for advances that will have a big impact on our lives and break down why they matter. Steve Kirsch: Vaccine Killing Millions, Treatments, VAERS, 5-Month Death Signal, Mystery Clots Embed 1.15K 'This Has Cost Millions of Lives': Steve Kirsch on Suppression of Repurposed Drugs and a Spike in Deaths 5 Months After Vaccine Rollout American Thought Leaders AMERICAN THOUGHT LEADERS JAN JEKIELEK Show more Loading comments. See my article on treatments. My experience is very typical.